Fill the knowledge gaps on antibiotic therapy of community-acquired pneumonia in pediatric age, in terms of optimal duration, oral step-down schedule evaluating effectiveness, safety and selection of antimicrobial resistance
Evaluate economic impact of antibiotic therapy in terms of cost-effectiveness
Implement the infrastructure that links study sites in order to share knowledge, develop study specific and general research skill straining programme and promote capacity development initiatives.
Objectives of PediCAP
Optimize antibiotic treatment for childhood pneumonia in low middle-income countries by a randomised trial using an innovative duration - response design
Understand if the rate of clinical cure is superior with co-amoxiclav vs amoxicillin oral step-down therapy
Clarify the optimal antibiotic treatment duration that achieves high rates of clinical cure while minimising length of hospital stay, toxicity and antimicrobial resistance
Detect if optimal antibiotic therapy duration vary by key characteristics, such as age or severity, suggesting that antibiotic duration should be personalised to specific subgroups