Goals of PediCAP

  • Fill the knowledge gaps on antibiotic therapy of community-acquired pneumonia in pediatric age, in terms of optimal duration, oral step-down schedule evaluating effectiveness, safety and selection of antimicrobial resistance
  • Evaluate economic impact of antibiotic therapy in terms of cost-effectiveness
  • Implement the infrastructure that links study sites in order to share knowledge, develop study specific and general research skill straining programme and promote capacity development initiatives.

Objectives of PediCAP

  • Optimize antibiotic treatment for childhood pneumonia in low middle-income countries by a randomised trial using an innovative duration - response design
  • Understand if the rate of clinical cure is superior with co-amoxiclav vs amoxicillin oral step-down therapy
  • Clarify the optimal antibiotic treatment duration that achieves high rates of clinical cure while minimising length of hospital stay, toxicity and antimicrobial resistance
  • Detect if optimal antibiotic therapy duration vary by key characteristics, such as age or severity, suggesting that antibiotic duration should be personalised to specific subgroups